Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
نویسندگان
چکیده
منابع مشابه
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus.
We examined the relationship between peripheral/hepatic insulin sensitivity and abdominal superficial/deep subcutaneous fat (SSF/DSF) and intra-abdominal visceral fat (VF) in patients with type 2 diabetes mellitus (T2DM). Sixty-two T2DM patients (36 males and 26 females, age = 55 +/- 3 yr, body mass index = 30 +/- 1 kg/m2) underwent a two-step euglycemic insulin clamp (40 and 160 mU. m(-2). min...
متن کاملEctopic fat, insulin resistance and non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the hepatic component of metabolic syndrome (MetS). NAFLD is an example of ectopic fat accumulation in a visceral organ that causes organ-specific disease, and affects risk of other related diseases such as type 2 diabetes and CVD. NAFLD is a spectrum of fat-associated liver conditions that can culminate in end stage liver disease, ...
متن کاملThe effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats
Introduction. The aim of this study was to investigate the effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats. Method. Forty male rats were divided into two groups: high-fat diet (HFD; n=32) and standard diet (C; n=8). After 10 weeks inducing obesity, eight rats from the HFD and C groups were sacrifi...
متن کاملDietary fat oxidation as a function of body fat.
BACKGROUND It is hypothesized that low dietary fat oxidation makes subjects prone to weight gain. OBJECTIVE The aim of the study was to determine dietary fat oxidation in normal, overweight, and obese subjects. DESIGN The subjects were 38 women and 18 men with a mean (+/-SD) age of 30+/-12 y and a body mass index (in kg/m2) of 25+/-4 (range: 18-39). Dietary fat oxidation was measured with d...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2004
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0802853